• Microbiome Analysis of Hospital Sink Drains

    Sink drains are notoriously characterized as reservoirs of pathogens causing nosocomial transmissions in hospitals worldwide. Outbreaks where sinks have been implicated as source of antibiotic resistant bacteria have upsurged over the last few years. To understand transmission dynamics University of Virginia School of Medicine has established a unique “Sink Lab” for this research. This one-of-the kind laboratory establishes UVa as worldwide frontrunners in investigating sink related antibiotic resistant bacteria and how they spread. RC is working with the UVa Sink Lab for genomic analysis of the sink biomass. RC is contributing to: Comparative genomic analysis of gram-negative bacterial isolates: The analysis aims at tracking the mobile genetic element blaKPC gene, which encodes for Klebsiella pneumoniae carbapenemase (KPC) enzyme that confers resistance to all beta lactam agents including penicillins, cephalosporins, monobactams and carbapenems.