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Bradycardia and Desaturation Events in Infants
Episodes of bradycardia and oxygen desaturation (BD) are common among preterm very low birthweight (VLBW) infants and their association with adverse outcomes such as bronchopulmonary dysplasia (BPD) is unclear. A better understanding of this relationship could lead to improved clinical interventions. RC is helping neonatologists describe BD events in a large single-NICU VLBW cohort and test the hypothesis that measures of BD in the neonatal period add to clinical variables to predict BPD or death and other adverse outcomes. RC has implemented statistical modeling and machine learning techniques to assess the primary outcome of BPD in the context of a combination of clinical characteristics (like birthweight and gestational age) and bedside monitor features.
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Heart Rate Ranges in Neonates
There are limited evidence-based published heart rate ranges for premature neonates. However, knowing heart rate reference ranges in the premature neonatal population can be beneficial for bedside assessment in the Neonatal Intensive Care Unit (NICU). RC is collaborating with clinical researchers in the Department of Pediatrics to establish baseline ranges for heart rate data in premature infants. These results are summarized from more than two billion data points collected via bedside monitoring in the NICU. RC staff has contributed data analysis and visualization expertise to aggregate the data, generate interactive heatmaps and produce tables of these ranges by gestational age.
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